Publications
Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates (Link)
Nature Cell Biology, 2023
Asif Ali, Rania Garde, Olivia C. Schaffer, Jared A. M. Bard, Kabir Husain, Samantha Keyport Kik, Kathleen A. Davis, Sofia Luengo-Woods, Maya G. Igarashi, D. Allan Drummond, Allison H. Squires, and David Pincus
Blue light receptor CRY1 regulates HSFA1d nuclear localization to promote plant thermotolerance (Link)
Cell Reports, 2023
Jie Gao, Runcong Zhang, Lanjie Zheng, Linhu Song, Manchun Ji, Shi Li, Jinxi Wang, Jianping Yang, Guozhang Kang, Paifeng Zhang, Yong Shi, Yongqing Jiao, David Pincus, Xu Zheng
Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response (Link)
eLife, 2023
Rania Garde, Abhyudai Singh, Asif Ali, David Pincus
Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response (Link)
Molecular Cell, 2022
Surabhi Chowdhary, Amoldeep S Kainth, Sarah Paracha, David S Gross, David Pincus
Primordial super-enhancers: heat shock-induced chromatin organization in yeast (Link)
Trends in Cell Biology, 2021
Amoldeep S Kainth, Surabhi Chowdhary, David Pincus, David S Gross
Subcellular localization of the J-protein Sis1 regulates the heat shock response (Link)
Journal of Cell Biology, 2021
Zoë A Feder, Asif Ali, Abhyudai Singh, Joanna Krakowiak, Xu Zheng, Vytas P Bindokas, Donald Wolfgeher, Stephen J Kron, David Pincus
Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition (Link)
Cell Reports, 2021
Peter Tsvetkov, Timothy J Eisen, Sven U Heinrich, Zarina Brune, Erinc Hallacli, Greg A Newby, Can Kayatekin, David Pincus, Susan Lindquist
Regulation of Hsf1 and the Heat Shock Response (Link)
Advances in Experimental Medicine and Biology, 2020
David Pincus
Multi-kinase control of environmental stress responsive transcription (Link)
PLoS One, 2020
Kieran Mace, Joanna Krakowiak, Hana El-Samad, David Pincus
Strategies for Engineering and Rewiring Kinase Regulation (Link)
Trends in Biochemical Sciences, 2020
James W McCormick, David Pincus, Orna Resnekov, Kimberly A Reynolds
m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis (Link)
Nature Communication, 2019
G Guy Bushkin, David Pincus, Jeffrey T Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P Bartel, Gerald R Fink
An update on the routine application of MALDI-TOF MS in clinical microbiology (Link)
Expert Review of Proteomics, 2019
Martin Welker, Alex Van Belkum, Victoria Girard, Jean-Philippe Charrier, David Pincus
Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness (Link)
Elife, 2019
Blake W Tye, Nicoletta Commins, Lillia V Ryazanova, Martin Wühr, Michael Springer, David Pincus, L Stirling Churchman
Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock (Link)
Cell Reports, 2019
Surabhi Chowdhary, Amoldeep S Kainth, David Pincus, David S Gross
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment (Link)
Molecular Cell, 2019
Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P H Ho, Tallie Noble, Jackson Sandoe, Yali Lou, Dirk Landgraf, Yelena Freyzon, Gregory Newby, Frank Soldner, Elizabeth Terry-Kantor, Tae-Eun Kim, Harald F Hofbauer, Michel Becuwe, Rudolf Jaenisch, David Pincus, Clary B Clish, Tobias C Walther, Robert V Farese Jr, Supriya Srinivasan, Michael A Welte, Sepp D Kohlwein, Ulf Dettmer, Susan Lindquist, Dennis Selkoe
Engineering allosteric regulation in protein kinases (Link)
Science Signaling, 2018
David Pincus, Jai P Pandey, Zoë A Feder, Pau Creixell, Orna Resnekov, Kimberly A Reynolds
Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome (Link)
Molecular Biology of the Cell, 2018
David Pincus, Jayamani Anandhakumar, Prathapan Thiru, Michael J Guertin, Alexander M Erkine, David S Gross
Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity (Link)
Cell Systems, 2018
Pau Creixell, Jai P Pandey, Antonio Palmeri, Moitrayee Bhattacharyya, Marc Creixell, Rama Ranganathan, David Pincus, Michael B Yaffe
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides (Link)
PNAS, 2018
Matthias C Truttmann, David Pincus, Hidde L Ploegh
Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity (Link)
Cell Reports, 2018
Xu Zheng, Ali Beyzavi, Joanna Krakowiak, Nikit Patel, Ahmad S Khalil, David Pincus
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity (Link)
Cell, 2018
Can Kayatekin, Audra Amasino, Giorgio Gaglia, Jason Flannick, Julia M Bonner, Saranna Fanning, Priyanka Narayan, M Inmaculada Barrasa, David Pincus, Dirk Landgraf, Justin Nelson, William R Hesse, Michael Costanzo, AMP T2D-GENES Consortium; Chad L Myers, Charles Boone, Jose C Florez, Susan Lindquist
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis (Link)
Molecular Cell, 2018
Eric J Solís, Jai P Pandey, Xu Zheng, Dexter X Jin, Piyush B Gupta, Edoardo M Airoldi, David Pincus, Vladimir Denic
Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response (Link)
ELife, 2018
Joanna Krakowiak, Xu Zheng, Nikit Patel, Zoë A Feder, Jayamani Anandhakumar, Kendra Valerius, David S Gross, Ahmad S Khalil, David Pincus
Serial Immunoprecipitation of 3xFLAG/V5-tagged Yeast Proteins to Identify Specific Interactions with Chaperone Proteins (Link)
Bio-Protocol, 2017
Xu Zheng, David Pincus
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response (Link)
PNAS, 2017
Matthias C Truttmann, Xu Zheng, Leo Hanke, Jadyn R Damon, Monique Grootveld, Joanna Krakowiak, David Pincus, Hidde L Ploegh
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation (Link)
Elife, 2016
Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis (Link)
Molecular Cell, 2016
Eric J Solís, Jai P Pandey, Xu Zheng, Dexter X Jin, Piyush B Gupta, Edoardo M Airoldi, David Pincus, Vladimir Denic